Research / Literature

Research Literature

Here you can search a selected list of NGAL literature relevant for research purposes.

Use the filters to the left to choose from a number of relevant areas or product relation.


Zhou X (2014) Toxicol App Pharmacol 280:30-35

The results showed that urinary NGAL and clusterin levels were significantly elevated in dogs on days 1 and 3 after administration of gentamicin, respectively.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/25034533
Date

Bangert K (2013) ASN Kidney Week

Analysis of plasma and urine NGAL monomer and homodimer in 151 Severe sepsis patients.

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Source
http://ngal.com/media/65680/bangert_k_2013_asn_-_fr-po017.pdf
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Kai K (2013) J Toxicol Sci 38(2):269-77

A sensitive urinary biomarker for acute kidney injury (AKI) was investigated in beagle dogs with nephrotoxicity induced by gentamicin

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Source
http://www.ncbi.nlm.nih.gov/pubmed/23535405
Date

Segev G (2013) J Vet Intern Med Sep 10

Acute kidney injury (AKI) is a common and often fatal disorder in dogs. Urine neutrophil gelatinase-associated lipocalin (NGAL)/creatinine ratio is a sensitive and specific biomarker of AKI in ninety-four dogs.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/24020513
Date

Daure E (2013) Res Vet Sci Sep 13

Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker in humans and dogs with kidney disease. This protein is expressed by many cells including renal tubular cells and neutrophils. The aim of this study was to evaluate the effect of urinary tract infection (UTI) on urinary NGAL (uNGAL) concentration in dogs.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/24074691
Date

Sohotnik R (2013) Am J Physiol Renal Physiol 304(8):F1099-104

Acute kidney injury (AKI) is a common clinical problem that still lacks effective treatment. Phosphodiesterase-5 (PDE5) inhibitors possess anti-apoptotic and anti-oxidant properties, making it a promising therapy for ischemia-reperfusion (I/R) injury of various organs. The present study evaluated the early nephroprotective effects of Tadalafil, a PDE5 inhibitor, in an experimental model of renal I/R.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/23364806
Date

Sirota JC (2013) BMC Nephrol 14:17

AKI is common following liver transplantation and is associated with significant morbidity and mortality. Biomarkers of AKI have not been well established in this setting but are needed to help guide patient care and facilitate development of novel therapeutics.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/23327592
Date

Polat M (2013) Ren Fail 35(3):352-6

To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/23391290
Date

Heyne N (2012) Transplantation

Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. 

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Source
http://www.ncbi.nlm.nih.gov/pubmed/22513480
Date

Ravlo K (2012) Pediatr Transplantation 16: 599–606

Kidney transplantation from a large donor to a small recipient, as in pediatric transplantation, is associated with an increased risk of thrombosis and DGF.

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Source
http://www.ncbi.nlm.nih.gov/pubmed?term=Early%20outcome%20in%20renal%20transplantation%20from%20large%20donors%20to%20small%20and%20size-matched%20recipients%20%E2%80%93%20A%20porcine%20experimental
Date

Nabity MB (2012) J Vet Intern Med 26: 282-293

Sensitive and specific biomarkers for early tubulointerstitial injury are lacking.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/22356524
Date

Bangert K (2012) ASN Kidney Week

The molecular forms of NGAL is a hot topic amongst NGAL researches these days.

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Source
http://ngal.com/media/55006/ngal_monomer_poster_asn-kidney_week.pdf
Date

Doi K (2012) Kidney International

Prerenal acute kidney injury (AKI) is thought to be a reversible loss of renal function without structural damage.

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Source
http://www.ncbi.nlm.nih.gov/pubmed?term=Mild%20elevation%20of%20urinary%20biomarkers%20in%20prerenal%20acute%20kidney%20injury
Date

Huber W (2012) J CLI 36:10-12

Sepsis frequently results in acute kidney injury (AKI). Although AKI markedly contributes to mortality in sepsis, its diagnosis is frequently delayed due to limitations of current biomarkers of renal impairment. Neutrophil-gelatinase-associated lipocalin (NGAL) has been demonstrated to be a biomarker of early AKI.

To download as pdf please click here 

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Source
http://www.cli-online.com/featured-articles/early-detection-of-acute-kidney-injury-in-sepsis-how-about-ngal/index.html
Date

Lippi G (2012) J Clin Chem and Lab Med

The neutrophil gelatinase associated lipo­calin (NGAL) has been identified as the most promising biomarker of acute kidney injury (AKI). This study was aimed to evaluate a NGAL immunoassay on Beckman Coulter AU 5822.

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Source
http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm.2011.839/cclm.2011.839.xml?rskey=E1Bklx&result=1&q=) immunoassay on Beckman Coulter
Date

Jeong TD (2012) Clin Transplant

An evaluation of the utility of urine and plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations as biomarkers of AKI during and after liver transplantation.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/22404749
Date

Hosgood SA (2012) J Surg Res 15;174(2):e85-90

Early urinary biomarkers are a useful means to determine graft injury. ET-1 and NGAL are more accurate in predicting the severity of ischemic injury compared with inflammatory markers

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Source
http://www.ncbi.nlm.nih.gov/pubmed/22221604
Date

Jochmans I (2011) Ann Surg 254:784–792

The objective is to investigate circulating biomarkers of initial graft injury in a porcine kidney autotransplant model.

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Source
http://www.ncbi.nlm.nih.gov/pubmed/21997818
Date

Jochmans I (2011) Transplant Proc 43:3486–3489

The enduring kidney graft shortage has led to the increasing use of expanded-criteria donors as well as kidneys donated after cardiac death, triggering the revival of machine perfusion preservation.

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Source
http://www.ncbi.nlm.nih.gov/pubmed?term=Neutrophil%20Gelatinase-Associated%20Lipocalin%2C%20a%20New%20Biomarker%20Candidate%20in%20Perfusate%20of%20Machine-Perfused%20Kidneys%3A%20A%20Porcine
Date

Ostermann M (2011) J CLI 35:10-12

Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising biomarker for acute kidney injury (AKI). The ultimate goal is for NGAL to enable clinicians to intervene as early as possible and to change the prognosis of AKI.

To download as pdf please click here

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Source
http://www.cli-online.com/index.php?id=3198
Date

Ricci Z (2011) Crit Care 29;15:R160

A study of Fenoldopam efficacy as a pretreatment to avoid AKI on cardiopulmonary bypass pediatric patients using NGAL for definition of AKI...

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Source
http://www.ncbi.nlm.nih.gov/pubmed/21714857
Date

Morishita Y (2011) Renal Failure

Acute kidney injury (AKI) has a profound impact on the morbidity and mortality of patients.

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Source
http://www.ncbi.nlm.nih.gov/pubmed?term=Establishment%20of%20Acute%20Kidney%20Injury%20Mouse%20Model%20by%200.75%25%20Adenine%20Ingestion
Date

Munshi R (2011) J Am Soc Nephrol

Monocyte chemoattractant protein 1 (MCP-1) mediates acute ischemic and toxic kidney injury, but  whether this can be used as a biomarker of acute kidney injury (AKI) is unknown.

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Source
http://www.ncbi.nlm.nih.gov/pubmed?term=MCP-1%20Gene%20Activation%20Marks%20Acute%20Kidney%20Injury
Date

Makris K (2009) Clin Chem Lab Med 47:79-82

Neutrophil gelatinase-associated lipocalin (NGAL), an iron-transporting protein rapidly accumulating in the kidney tubules and urine after nephrotoxic and ischemic insults...

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Source
http://www.ncbi.nlm.nih.gov/pubmed/19055468
Date

Nickolas TL (2008) Ann Intern Med 3;148:810-9

To test the sensitivity and specificity of a single measurement of urinary neutrophil gelatinase-associated lipocalin (NGAL) and other urinary proteins to detect acute kidney injury...

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Source
http://www.ncbi.nlm.nih.gov/pubmed/18519927
Date